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DURABLE

DURABLE


Delivering a Unified Research Alliance of Biomedical and public health Laboratories against Epidemics

Delivering a Unified Research Alliance of Biomedical and public health Laboratories against Epidemics

DURABLE in figures

Duration 4 years

2023 – 2027

Budget 30M

25M funded by HERA

19 Partners &
2 Affiliated Entity

in 15 EU Countries

170 Experts

48 Tasks

11 distributed in WPs

10 Specific Objectives

17 Milestones

29 Deliverables

DURABLE in figures

Duration

4 years 2023 – 2027

Budget

30M 25M funded by HERA

19 Partners & 2 Affiliated Entity

in 15 EU Countries

170 Experts

48 Tasks

11 distributed in WPs

10 Specific Objectives

17 Milestones

29 Deliverables

Durable coordinator
Dr. Jean-Claude Manuguerra | Institut Pasteur, FR

“Our network DURABLE represents an important step in improving Europe preparedness and readiness to pandemic and other large-scale health threats”

About the project

Project period: 1/2/2023 – 31/1/2027
Outbreaks of infectious diseases are increasing due to multiple local and global interaction changes disrupting the fragile balance of the complex human-animal-environment ecosystem. The increased frequency and complexity of health threats require a different, unified form of preparedness and a coordinated, fast, reliable and effective emergency response.

Outbreaks of infectious diseases are increasing due to multiple local and global interaction changes disrupting the fragile balance of the complex human-animal-environment ecosystem. The increased frequency and complexity of health threats require a different, unified form of preparedness and a coordinated, fast, reliable and effective emergency response.

DURABLE is a tailored solution to this recognised need – a strong network of world-class basic and translational research institutes and public health centres across Europe with an outstanding track record in public health support with global reach. DURABLE aims to provide high-quality scientific information in record time to support HERA’s decision-making in preparing for and responding to cross-border health threats and assessing the impact of countermeasures.

DURABLE will coordinate a global collaboration, from pathogen detection, evolutionary analysis and threat characterisation, with One Health approach, to data and information collection and sharing, for optimal threat response. DURABLE is a unique multidisciplinary consortium with complementary expertise to meet this challenge and build productive interactions with HERA and other stakeholders.

Due to their outstanding track record and experience in the field, the DURABLE consortium is competent from day one. DURABLE will develop and validate a roadmap for rapid deployment of key countermeasures, test the robustness of the network, and assess key aspects of its emergency mode when simula­ting or dealing with identified threats. Additionally, DURABLE will focus on long-term sustainability by focusing on capacity building, training the next generation of researchers and developing pandemic preparedness training modules for the network and beyond.

Project objectives

DURABLE will be a one-stop shop for diagnostics, research, preparedness and response to current and future health threats for the benefit of citizens in the EU and worldwide.

DURABLE will establish a sustainable network of laboratories and research institutes that can address the barriers of better preparedness, and provide alerts, real-time scientific data and integrated analyses to HERA.

DURABLE will develop and use both non-targeted and targeted methods for identification of known and new threats


DURABLE will coordinate, integrate, analyse and share the output for rapid and direct use in public health decision making.

DURABLE will develop targeted studies to guide further evidence gathering in response to alerts

co-coordinator
Dr. Marion Koopmans | Erasmus Medical Center, NL

“DURABLE will be uniquely positioned to support HERA in responding to future health emergencies, by providing timely scientific intelligence and by translating them into operational recommendations”


Durable partner Martin Beer has studied H5N1 clade 2.3.4.4b dynamics in experimentally infected calves and cows. Their data suggest that in addition to H5N1 B3.13, other HPAIV H5N1 strains have the potential to replicate in the udder of cows and that milk and milking procedures, rather than respiratory spread, are likely the primary routes of H5N1 transmission between cattle.

Full article in Nature can be found here: H5N1 clade 2.3.4.4b dynamics in experimentally infected calves and cows | Nature